Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe3O4 nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective

• nanostructures employed, particular emphasis has been placed on iron oxide (Fe3O4) nanoparticles. The biocompatibility and low toxicity of Fe3O4 nanoparticles have garnered significant attention in magnetic drug delivery for cancer diagnosis and treatment, primarily because of their magnetic properties [11][12

• ]. The crystal structure of Fe3O4 nanoparticles can be tailored to allow for precise control, and these nanostructures find utility in various production processes. Magnetite nanoparticles exhibit superparamagnetic behavior due to the negligible energy barrier in the hysteresis of the particles

Ferromagnetic resonance spectra of linear magnetosome chains

• Elizaveta M. Gubanova and
• Nikolai A. Usov

Beilstein J. Nanotechnol. 2024, 15, 157–167, doi:10.3762/bjnano.15.15

• field acting on a separate nanoparticle can be calculated as a derivative of the total chain energy W = Wmc + Wmd + WZ: The cubic magneto-crystalline anisotropy energy of Fe3O4 nanoparticles is where V = πD2/6 is the volume of spherical particle, Kc is the cubic anisotropy constant, and (e1i, e2i, e3i

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• materials with other functional materials have been found to be useful. Covalent organic frameworks (COFs) are a new class of organic polymers containing B, C, Si, N, and O in their backbones. Conjugation of COFs with Fe3O4 nanoparticles will yield a two to three times higher PCE than that of bare Fe3O4

• nanoparticles. COF–CuSe can also increase the photothermal conversion efficiency up to 26%, which is higher than that of COF-Fe3O4 [36]. Nanoarchitectonics of photothermal materials The photon-to-heat conversion efficiency of nanomaterials depends on intrinsic factors, such as shape, size, crystallinity, and

Two-step single-reactor synthesis of oleic acid- or undecylenic acid-stabilized magnetic nanoparticles by thermal decomposition

• Mykhailo Nahorniak,
• Pamela Pasetto,
• Jean-Marc Greneche,
• Volodymyr Samaryk,
• Sandy Auguste,
• Anthony Rousseau,
• Nataliya Nosova and
• Serhii Varvarenko

Beilstein J. Nanotechnol. 2023, 14, 11–22, doi:10.3762/bjnano.14.2

• , cubic, octahedral) is another great advantage of this method [17][18]. It has been previously reported that by using oleylamine as a stabilizer, the decomposition of thermally unstable Fe(III) acetylacetonate was observed at temperatures above 150 °C, followed by the formation of 10–16 nm FeO/Fe3O4

• nanoparticles [19][20]. To synthesize magnetite nanoparticles, an additional component (e.g., 1,2-hexadecandiol) was introduced into the system [21]. According to the most common method, a dispersion of magnetite nanoparticles is obtained via thermolysis of commercial or separately synthesized Fe(III) oleate at

Non-stoichiometric magnetite as catalyst for the photocatalytic degradation of phenol and 2,6-dibromo-4-methylphenol – a new approach in water treatment

• Joanna Kisała,
• Anna Tomaszewska and
• Przemysław Kolek

Beilstein J. Nanotechnol. 2022, 13, 1531–1540, doi:10.3762/bjnano.13.126

• octahedral iron chain handles its conductivity and redox properties, causing the magnetite to initialize oxidation/reduction reactions. Fe3O4 nanoparticles have been used as a photocatalyst for the degradation of azo dyes [15], for wastewater treatment [16][17], for water decomposition, and for Cr(VI

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• effects of alumina-coated Fe3O4 nanoparticles against bacteria upon exposure to NIR light [13]. Further studies with esophageal cancer demonstrate that Fe3O4 nanoparticles induce hyperthermia post absorption to suppress tumor growth in a dosage-dependent manner [14]. However, due to very high dosage

• show that clustered magnetic Fe3O4 nanoparticles induce a redshift in the light absorption spectra, which enhances light absorbance within the NIR region and improves their utilization as photosensitizers during PTT to ablate lung tumors [16]. However, the role of Fe3O4 nanoparticle clusters in the

• nanoclusters as PTT agents both in vitro and in vivo, and finally explored the putative molecular mechanisms underlying the observed therapeutic effects. Results and Discussion Properties of Fe3O4 nanoparticle clusters (NPCs) The as-synthesized individual Fe3O4 nanoparticles were evenly dispersed in chloroform

A comprehensive review on electrospun nanohybrid membranes for wastewater treatment

• Senuri Kumarage,
• Imalka Munaweera and
• Nilwala Kottegoda

Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10

• gravity-driven oil separation through the membrane was fast with a separation efficiency greater than 99% [71]. Jiang et al. fabricated a PVDF/PS magnetic nanofibrous membrane by selective inclusion of Fe3O4 nanoparticles in PS via a two-nozzle electrospinning process (Figure 3). Integration of magnetic

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• -assisted control of the behavior of MNPs makes them suitable candidates for targeted drug delivery, hyperthermia, biosensors, magnetic resonance imaging (MRI), and magnetic separation [9][10]. Magnetite (Fe3O4) nanoparticles (NPs), belonging to the spinel ferrite class, are the most extensively studied

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• FMSM had a two-layer nanoparticle coating. In order to drive the FMSM by an external magnetic field, Yang et al. coated magnetic Fe3O4 nanoparticles onto the outside surface of the spores for magnetization, and conjugated carbon dots onto the outside and inside walls of the magnetic spores. The MagDisk

Magnetic-field-assisted synthesis of anisotropic iron oxide particles: Effect of pH

• Andrey V. Shibaev,
• Petr V. Shvets,
• Darya E. Kessel,
• Roman A. Kamyshinsky,
• Anton S. Orekhov,
• Sergey S. Abramchuk,
• Alexei R. Khokhlov and
• Olga E. Philippova

Beilstein J. Nanotechnol. 2020, 11, 1230–1241, doi:10.3762/bjnano.11.107

• synthesized material were investigated using electron diffraction, Raman spectroscopy, and transmission electron microscopy. It was shown that the morphology of the reaction product strongly depends on the amount of OH− ions in the reaction mixture, varying from Fe3O4 nanorods to spherical Fe3O4 nanoparticles

• have very different vibrational bands [46][47]. The Raman spectrum of the sample synthesized at R = 2.1 is shown in Figure 6 (blue curve). The data shows that the main band (672 cm−1) coincides with the main vibrational mode of magnetite (A1g) [48][49], thus proving that Fe3O4 nanoparticles were

Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• Gd-DTPA (gadolinium diethylenetriaminepentacetate), are highly advantageous for diagnostic imaging, since they generate bright images, the renal toxicity of Gd-based contrast agents should not be ignored [18][19]. On the other hand, T2 contrast agents, such as Fe3O4 nanoparticles, have a lower

• Fe3O4 nanoparticles have been extensively investigated as MRI contrast agents due to their biocompatibility, many recent studies concerning T1–T2 dual-mode contrast agents use Fe3O4 nanoparticles [22]. For example, Zhou et al. [23] demonstrated that uniformly distributed Gd-embedded Fe3O4 nanoparticles

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• ], including magnetic nanoparticles (MNPs) that can be exploited for their catalytic properties [10] and magnetic separation in pre-concentrating the analyte [11][12][13][14][15][16]. The most common magnetic nanoparticles used for this purpose are magnetite (Fe3O4) nanoparticles, which have a stronger

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• functional groups. In this study, magnetite (Fe3O4) nanoparticles were synthetized by coprecipitation of iron(II) chloride and iron(III) chloride with ammonia and subsequently oxidized with hydrogen peroxide under mild acidic conditions. The resulting maghemite (γ-Fe2O3) has the benefit of higher chemical

Fe₃O₄ nanoparticles as a saturable absorber for giant chirped pulse generation

• Ji-Shu Liu,
• Xiao-Hui Li,
• Abdul Qyyum,
• Yi-Xuan Guo,
• Tong Chai,
• Hua Xu and
• Jie Jiang

Beilstein J. Nanotechnol. 2019, 10, 1065–1072, doi:10.3762/bjnano.10.107

• 710119, China Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha and 410083, China 10.3762/bjnano.10.107 Abstract Fe3O4 nanoparticles (FONPs) are magnetic materials with a small band gap and have well-demonstrated

• , and optical modulators. Keywords: erbium laser; Fe3O4 nanoparticles; fiber lasers; saturable absorber; Introduction Fe3O4 nanoparticles (FONPs) are excellent magnetic materials, which allows for many applications in various fields such as medical transmission, microwave devices, and optical devices

• fiber laser based on a FONP SA has a robust structure and good stability and can potentially be used for ultrafast photonics and could play an important role in other nonlinear photonics applications. Results and Discussion A schematic of the Er-doped fiber laser based on Fe3O4 nanoparticles is shown in

Tungsten disulfide-based nanocomposites for photothermal therapy

• Tzuriel Levin,
• Hagit Sade,
• Rina Ben-Shabbat Binyamini,
• Maayan Pour,
• Iftach Nachman and
• Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

• . Then, a concentrated (24 wt %) NH4OH solution (750 µL) was added, resulting in the immediate formation of a black precipitate of magnetite (Fe3O4) nanoparticles. Sonication was continued for an additional 10 min. The liquid was decanted with the help of magnetic separation, using a 0.5 T magnet. The

Magnetic-field sensor with self-reference characteristic based on a magnetic fluid and independent plasmonic dual resonances

• Kun Ren,
• Xiaobin Ren,
• Yumeng He and
• Qun Han

Beilstein J. Nanotechnol. 2019, 10, 247–255, doi:10.3762/bjnano.10.23

• field. It depends on the type of carrier liquid and the concentration of the magnetic fluid. nsat is the saturation value of the refractive index. In this paper, the magnetic fluid is a colloidal solution consisting of Fe3O4 nanoparticles dispersed in water with n0 = 1.4612. The concentration of the

Nanocellulose: Recent advances and its prospects in environmental remediation

• Katrina Pui Yee Shak,
• Yean Ling Pang and
• Shee Keat Mah

Beilstein J. Nanotechnol. 2018, 9, 2479–2498, doi:10.3762/bjnano.9.232

• increase its aromatic character, anion exchange capability, and hydrophilic nature of cellulose. Cellulose could also act as a stabilizer for the Fe3O4 nanoparticles to prevent crystal growth and aggregation of particles. In general, magnetic iron oxide is anchored in the polymer matrix to induce magnetic

Synthesis of a MnO₂/Fe₃O₄/diatomite nanocomposite as an efficient heterogeneous Fenton-like catalyst for methylene blue degradation

• Zishun Li,
• Xuekun Tang,
• Kun Liu,
• Jing Huang,
• Yueyang Xu,
• Qian Peng and
• Minlin Ao

Beilstein J. Nanotechnol. 2018, 9, 1940–1950, doi:10.3762/bjnano.9.185

• nanocomposite is synthesized and then used as heterogeneous Fenton-like catalyst to degrade the organic pollutant methylene blue (MB) with the activation of PMS. The characterization results show that the Fe3O4 nanoparticles and nanoflower-like MnO2 are evenly distributed layer-by-layer on the surface of

• /diatomite. These peaks match well with the (220), (311), (400), (422), (511) and (440) plane spacings of cubic magnetite (JCPDS file No. 19-0629), suggesting the Fe3O4 nanoparticles are successfully coating the surface of diatomite [21]. In addition, the characteristic peaks of magnetite have a large FWHM

• , revealing the small size of the loaded Fe3O4 particles. The average crystal size of the Fe3O4 nanoparticles estimated with the Scherrer formula is about 10 nm. After the hydrothermal treatment with KMnO4, no new characteristic peaks are detected in the pattern of the as-prepared MnO2/Fe3O4/diatomite

Enzymatically promoted release of organic molecules linked to magnetic nanoparticles

• Chiara Lambruschini,
• Silvia Villa,
• Luca Banfi,
• Fabio Canepa,
• Fabio Morana,
• Annalisa Relini,
• Paola Riani,
• Renata Riva and
• Fulvio Silvetti

Beilstein J. Nanotechnol. 2018, 9, 986–999, doi:10.3762/bjnano.9.92

• to the loss of material during the workup and purification. Preliminary experiments of conjugation with Fe3O4 nanoparticles functionalized with 3-aminopropyltriethoxysilane (APTES) showed that the purification of 6 was essential. In fact, the presence of excess PhSiH3 and the residues of Pd were

Anchoring Fe₃O₄ nanoparticles in a reduced graphene oxide aerogel matrix via polydopamine coating

• Błażej Scheibe,
• Radosław Mrówczyński,
• Natalia Michalak,
• Karol Załęski,
• Michał Matczak,
• Mateusz Kempiński,
• Zuzanna Pietralik,
• Mikołaj Lewandowski,
• Stefan Jurga and
• Feliks Stobiecki

Beilstein J. Nanotechnol. 2018, 9, 591–601, doi:10.3762/bjnano.9.55

• , immobilizing the particles in the matrix and, at the same time, improving the aerogel structure. Polydopamine coating does not affect the magnetic properties of magnetite particles, making the fabricated materials promising for industrial applications. Keywords: aerogel; composite; Fe3O4 nanoparticles

• reference rGO aerogel, is related to the stabilization of rGO aerogel structure by Fe3O4 nanoparticles that anchor at the GO defect sites via monodente or bidentate coordination of iron with carboxylic groups during hydrogel formation [49]. In the case of the rGO-PDA@Fe3O4 sample, this effect is even more

• the lattice parameter and decrease of the C–C bond strength due to anchored Fe3O4 nanoparticles or Fe doping at the defect sites. At lower excitation energies, the FWHMG values were comparable to those of rGO reference sample (within the range of the measurement error). The FWHMD values differed along

Characterization of ferrite nanoparticles for preparation of biocomposites

• Urszula Klekotka,
• Magdalena Rogowska,
• Dariusz Satuła and
• Beata Kalska-Szostko

Beilstein J. Nanotechnol. 2017, 8, 1257–1265, doi:10.3762/bjnano.8.127

• -assembly also causes worse particle separation, as seen in the TEM images. It is also observed that after modification of the inorganic core, the size distribution increases in comparison to Fe3O4 nanoparticles (Table 1), while the average size of the ferrite core decreases. This suggests that Co, Mn, and

Antitumor magnetic hyperthermia induced by RGD-functionalized Fe₃O₄ nanoparticles, in an experimental model of colorectal liver metastases

• Oihane K. Arriortua,
• Eneko Garaio,
• Borja Herrero de la Parte,
• Maite Insausti,
• Luis Lezama,
• Fernando Plazaola,
• Jose Angel García,
• Jesús M. Aizpurua,
• Maialen Sagartzazu,
• Mireia Irazola,
• Nestor Etxebarria,
• Ignacio García-Alonso,
• Alberto Saiz-López and
• José Javier Echevarria-Uraga

Beilstein J. Nanotechnol. 2016, 7, 1532–1542, doi:10.3762/bjnano.7.147

• cells, being bound the RGD peptides by “click chemistry” due to its selectivity and applicability. The thermal decomposition of iron metallo-organic precursors yield homogeneous Fe3O4 nanoparticles that have been properly functionalized with RGD peptides, and the preparation of magnetic fluids has been

Microwave synthesis of high-quality and uniform 4 nm ZnFe₂O₄ nanocrystals for application in energy storage and nanomagnetics

• Christian Suchomski,
• Ben Breitung,
• Ralf Witte,
• Michael Knapp,
• Sondes Bauer,
• Tilo Baumbach,
• Christian Reitz and
• Torsten Brezesinski

Beilstein J. Nanotechnol. 2016, 7, 1350–1360, doi:10.3762/bjnano.7.126

• fact that the formation of acetophenone can be ruled out on the basis of the GC-MS data (Supporting Information File 1, Figure S1). The latter compound is found in the microwave synthesis of Fe3O4 nanoparticles under identical conditions due to partial oxidation of 1-phenylethanol (data not shown

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• employed in case of other DDS such as biodegradable polymers, which co-assemble into composite micelles [10]. Another type of common drug carriers includes nanoparticles. Magnetic Fe3O4 nanoparticles are often employed because they give possibility to control the transport by applying external magnetic

Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection

• Dinusha N. Udukala,
• Hongwang Wang,
• Sebastian O. Wendel,
• Aruni P. Malalasekera,
• Thilani N. Samarakoon,
• Asanka S. Yapa,
• Gayani Abayaweera,
• Matthew T. Basel,
• Pamela Maynez,
• Raquel Ortega,
• Yubisela Toledo,
• Leonie Bossmann,
• Colette Robinson,
• Katharine E. Janik,
• Olga B. Koper,
• Ping Li,
• Massoud Motamedi,
• Daniel A. Higgins,
• Gary Gadbury,
• Gaohong Zhu,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2016, 7, 364–373, doi:10.3762/bjnano.7.33

• characterization of the nanoplatforms for protease detection is described in detail in [19]. In short, water-dispersible Fe/Fe3O4 nanoparticles featuring dopamine ligands [47], TCPP [48], and cyanine 5.5 [49] were synthesized according to established procedures. The oligopeptides used as consensus sequences, which

• protease detection. For each protease, a highly selective oligopeptide is used to tether tetrakis-carboxy-phenyl-porphyrin (TCPP) to the nanoparticle. Cyanine 5.5 is linked permanently to the Fe/Fe3O4 nanoparticles. Figure 1 is reproduced from [23] with permission. Mechanistic scheme of the “light switch